Time-Course Characterization of High-Intensity Focused Ultrasound Exposure Using B-Mode Ultrasound Imaging

Authors

  • Matthew Jahns Biomedical Engineering PhD Student at Dalhousie University
  • Rob Adamson Dalhousie University

Abstract

High-Intensity Focused Ultrasound (HIFU) is an emerging non-invasive surgical technique. HIFU systems are generally designed to deliver a fixed amount of energy to tissue, but because the tissue thermal response is variable across patients and tissue type, this approach can often lead to underdosing or overdosing.  In order to improve the dosing precision in HIFU we are investigating real time monitoring of the energy deposition process through high-frequency diagnostic ultrasound imaging. Ultimately the development of monitoring techniques will allow real-time adjustment of energy to obtain optimal treatment.

We present results from an exploratory study into the transient response of HIFU exposure in phantoms and animal tissue.  Imaging was performed with a Visual Sonics Vevo 2100 50 MHz ultrasound imaging system with 40µm resolution and a B-mode frame rate of 1kHz.  HIFU deposition was performed in phantoms and chicken breast using a commercial HIFU system across a range of energy levels. HIFU deposition points had an exposure duration less than 50ms and a focal spot diameter less than 250µm. The high temporospatial resolution of the Vevo 2100 allows for a unique time-course characterization of the material response to HIFU exposure.

The transient response observed in the B-mode ultrasound images is due to a combination of the thermal-acoustic lens effects, thermal expansion of the medium and cavitation. Images were acquired across a range of HIFU energy levels and analyzed to determine the energy dependence of various effects. These preliminary experiments will inform the development of new image analysis techniques for determining dosage received in tissue during HIFU exposure.

Additional Files

Published

2015-09-08

How to Cite

1.
Jahns M, Adamson R. Time-Course Characterization of High-Intensity Focused Ultrasound Exposure Using B-Mode Ultrasound Imaging. Canadian Acoustics [Internet]. 2015 Sep. 8 [cited 2024 Apr. 24];43(3). Available from: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/2794

Issue

Vol. 43 No. 3 (2015)

Section

Proceedings of the Acoustics Week in Canada

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