Development of prototype phased array ultrasound systems for hyperthermia and targeted drug delivery
Keywords:Ablation, Cavitation, Computer simulation, Controlled drug delivery, Drug products, Thermal effects, High power phased array ultrasound (US) systems, Hyperthermia, Targeted drug delivery, Thermal ablation
AbstractThe development of high power phased array ultrasound (US) systems used to generate and direct both moderate temperature hyperthermia and high temperature thermal ablation is discussed. The effects of hyperthermia and cavitation can also be utilized as activation mechanisms in targeted drug delivery. The one-dimensional prototype arrays are constructed from PZT (Navy Type III) and double-sized copper-clad Pyralux baffles. The system is tested after the ultrasound phased array is mounted in a water tank. It is found that the shape of the measured field in the direction of the array sampling is similar to the results obtained from computer simulations.
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