Parametric analysis of ultrasound backscatter signals for monitoring cancer cell structural changes during cancer treatment

Authors

  • Harshitha Nallapareddy Dept. of Elec. and Comp. Engg., Ryerson University, Toronto, Ont., Canada
  • Sridhar Krishnan Dept. of Elec. and Comp. Engg., Ryerson University, Toronto, Ont., Canada
  • Michael Kolios Dept. of Elec. and Comp. Engg., Ryerson University, Toronto, Ont., Canada

Keywords:

Cell death, Classification (of information), Electromagnetic wave backscattering, Error analysis, Reflection, Signal analysis, Tumors, Biomedical signals, Cancer therapy, Non-invasive monitoring, Parametric analysis, Signal classification

Abstract

High frequency ultrasound backscattered signals (20 - 60 MHz) from normal and apoptotic cell pellets differ in their backscatter intensity, and analyzing these signals could assist in the non-invasive monitoring of cancer therapy. In this work, the reflection coefficients of the lattice prediction error filter are used as feature set for parametric analysis and signal classification. The ultrasound (US) backscattered signal databases consisted of combinations of treated (apoptotic) and untreated (normal) cells mixed in different proportions. A 40 MHz commercial ultrasound imaging system was used. A classification accuracy of 97-100% for normal and apoptotic signals were obtained with a model order 15. The positive results ascertain that the reflection coefficient is a potential tool for analyzing biomedical signals such as US backscattered signals.

Published

2007-06-01

How to Cite

1.
Nallapareddy H, Krishnan S, Kolios M. Parametric analysis of ultrasound backscatter signals for monitoring cancer cell structural changes during cancer treatment. Canadian Acoustics [Internet]. 2007Jun.1 [cited 2021May13];35(2):47-54. Available from: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/1877

Issue

Vol. 35 No. 2 (2007)

Section

Technical Articles

Copyright on articles is held by the author(s). The corresponding author has the right to grant on behalf of all authors and does grant on behalf of all authors, a worldwide exclusive licence (or non-exclusive license for government employees) to the Publishers and its licensees in perpetuity, in all forms, formats and media (whether known now or created in the future)
i)    to publish, reproduce, distribute, display and store the Contribution;
ii)    to translate the Contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or, abstracts of the Contribution;
iii)    to exploit all subsidiary rights in the Contribution,
iv)    to provide the inclusion of electronic links from the Contribution to third party material where-ever it may be located;
v)    to licence any third party to do any or all of the above.