Recovery of vascular function after exposure to a single bout of vibration
Keywords:Control level, Repeated measures, Residual effects, Single exposure, Vascular functions, Vibration exposure
AbstractA model of vibration-induced dysfunction is used to determine the presence of residual effects of a single exposure to vibration on peripheral vascular function and residual effects, the number of days of rest needed for vascular function to recover after a single exposure. Rats were acclimated to the laboratory for 1 week prior to the beginning of the experiment. All data were expressed as a percent change from baseline and were analyzed using 2-way repeated measures ANOVAs. One day following exposure to vibration, vasoconstriction in response to UK-14304 is enhanced in vibrated arteries as compared to controls. The results also show that vascular responsiveness returns to control levels after a 7-day recovery period. Work rotation schedules that allow more than two days of recovery between subsequent bouts of vibration exposure may help reduce the risk of developing the vascular dysfunction that is characteristic of HAVS.
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