Characterization of frequency-dependent responses of sensory nerve function to repetitive vibration

Authors

  • Kristine Krajnak Engineering and Controls Technology Branch, National Institute for Occupational Safety' and Health, Morgantown, WV 26506, United States
  • Stacy Waugh Engineering and Controls Technology Branch, National Institute for Occupational Safety' and Health, Morgantown, WV 26506, United States
  • Claud Johnson Engineering and Controls Technology Branch, National Institute for Occupational Safety' and Health, Morgantown, WV 26506, United States
  • Roger Miller Engineering and Controls Technology Branch, National Institute for Occupational Safety' and Health, Morgantown, WV 26506, United States
  • Shenqiao Li Biostatistics and Epidemiology Branch, National Institute for Occupational Safety' and Health, Morgantown, WV 26506, United States
  • Michael L. Kashon Biostatistics and Epidemiology Branch, National Institute for Occupational Safety' and Health, Morgantown, WV 26506, United States

Keywords:

Gene expression, Polymerase chain reaction, Rats, Ad libitum, Candidate genes, Different frequency, Frequency-dependent, Peripheral nerves, Quantitative PCR, Sensory nerves, Sprague-Dawley rats, Transcutaneous electrical stimulation, Vibration exposure

Abstract

The frequency-dependent effects of repeated vibration exposures on peripheral nerve function and biology were characterized. Male Sprague-Dawley rats were used and were maintained in an AALAC-accredited vivarium under a 12:12 LD cycle with food and water available ad libitum. Fiber functions were assessed using transcutaneous electrical stimulation at 3 different frequencies. Changes in gene expression were measured in the ventral tail nerve and DRG using total rat genome arrays to identify candidate genes and changes were verified using quantitative PCR. The results show no significant changes in the CPTs at 250 or Hz. Between days 1 and 9, there is a significant decrease in the 2000 Hz CPT in rats exposed to vibration at all frequencies. nerves from rats exposed to vibration at 250 Hz displayed a significant reduction in myelin thickness and an increase in the area stained for albumin.

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Published

2011-06-01

How to Cite

1.
Krajnak K, Waugh S, Johnson C, Miller R, Li S, Kashon ML. Characterization of frequency-dependent responses of sensory nerve function to repetitive vibration. Canadian Acoustics [Internet]. 2011 Jun. 1 [cited 2021 Dec. 3];39(2):92-3. Available from: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/2373

Issue

Section

Proceedings of the Acoustics Week in Canada