Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay

Authors

  • Adrienne L. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Jaina Negandhi Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Cullen Allemang Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Lisa D’Alessandro Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Robert V. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Department of Otolaryngology-Head and Neck Surgery, University of Toronto and Hospital for Sick Children, 555 University Ave., Toronto, ON, Canada, M5G1X8

Abstract

Closed-field stimulation of one ear, at high sound intensity, will activate both ears because of bone/soft tissuetransmission of the acoustic signal across the skull. In human psychophysics and in clinical audiometry a knowledgeof interaural attenuation values is important, particularly when assessing asymmetrical hearing loss or in studies of monaural hearing. Similarly, in testing monaural hearing in experimental animal studies, acoustic cross-over can result in erroneous conclusions about hearing function. The mouse has become a widely used animal model for various types of hearing loss, especially those relating to gene mutations, and also for age related deafness (presbycusis). In the present study we have measured acoustic cross-over in this species using a novel bio-assay technique based on auditory brainstem evoked responses (ABR). We report here for the mouse, an interaural attenuation of 37-45dB for click and 32kHz toneburst

How to Cite

1.
Harrison AL, Negandhi J, Allemang C, D’Alessandro L, Harrison RV. Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay. Canadian Acoustics [Internet]. 1 [cited 2021Jun.20];41(1). Available from: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/2597

Issue

Vol. 41 No. 1 (2013)

Section

Article - Hearing Sciences

Copyright on articles is held by the author(s). The corresponding author has the right to grant on behalf of all authors and does grant on behalf of all authors, a worldwide exclusive licence (or non-exclusive license for government employees) to the Publishers and its licensees in perpetuity, in all forms, formats and media (whether known now or created in the future)
i)    to publish, reproduce, distribute, display and store the Contribution;
ii)    to translate the Contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or, abstracts of the Contribution;
iii)    to exploit all subsidiary rights in the Contribution,
iv)    to provide the inclusion of electronic links from the Contribution to third party material where-ever it may be located;
v)    to licence any third party to do any or all of the above.