Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay

Authors

  • Adrienne L. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Jaina Negandhi Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Cullen Allemang Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Lisa D’Alessandro Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Robert V. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Department of Otolaryngology-Head and Neck Surgery, University of Toronto and Hospital for Sick Children, 555 University Ave., Toronto, ON, Canada, M5G1X8

Abstract

Closed-field stimulation of one ear, at high sound intensity, will activate both ears because of bone/soft tissuetransmission of the acoustic signal across the skull. In human psychophysics and in clinical audiometry a knowledgeof interaural attenuation values is important, particularly when assessing asymmetrical hearing loss or in studies of monaural hearing. Similarly, in testing monaural hearing in experimental animal studies, acoustic cross-over can result in erroneous conclusions about hearing function. The mouse has become a widely used animal model for various types of hearing loss, especially those relating to gene mutations, and also for age related deafness (presbycusis). In the present study we have measured acoustic cross-over in this species using a novel bio-assay technique based on auditory brainstem evoked responses (ABR). We report here for the mouse, an interaural attenuation of 37-45dB for click and 32kHz toneburst

Additional Files

How to Cite

1.
Harrison AL, Negandhi J, Allemang C, D’Alessandro L, Harrison RV. Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay. Canadian Acoustics [Internet]. 2013 Mar. 1 [cited 2024 Apr. 19];41(1). Available from: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/2597

Issue

Vol. 41 No. 1 (2013)

Section

Article - Hearing Sciences

License

Author Licensing Addendum

This Licensing Addendum ("Addendum") is entered into between the undersigned Author(s) and Canadian Acoustics journal published by the Canadian Acoustical Association (hereinafter referred to as the "Publisher"). The Author(s) and the Publisher agree as follows:

  1. Retained Rights: The Author(s) retain(s) the following rights:

    • The right to reproduce, distribute, and publicly display the Work on the Author's personal website or the website of the Author's institution.
    • The right to use the Work in the Author's teaching activities and presentations.
    • The right to include the Work in a compilation for the Author's personal use, not for sale.

  2. Grant of License: The Author(s) grant(s) to the Publisher a worldwide exclusive license to publish, reproduce, distribute, and display the Work in Canadian Acoustics and any other formats and media deemed appropriate by the Publisher.

  3. Attribution: The Publisher agrees to include proper attribution to the Author(s) in all publications and reproductions of the Work.

  4. No Conflict: This Addendum is intended to be in harmony with, and not in conflict with, the terms and conditions of the original agreement entered into between the Author(s) and the Publisher.

  5. Copyright Clause: Copyright on articles is held by the Author(s). The corresponding Author has the right to grant on behalf of all Authors and does grant on behalf of all Authors, a worldwide exclusive license to the Publisher and its licensees in perpetuity, in all forms, formats, and media (whether known now or created in the future), including but not limited to the rights to publish, reproduce, distribute, display, store, translate, create adaptations, reprints, include within collections, and create summaries, extracts, and/or abstracts of the Contribution.