Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay

Authors

  • Adrienne L. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Jaina Negandhi Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Cullen Allemang Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Lisa D’Alessandro Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Robert V. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Department of Otolaryngology-Head and Neck Surgery, University of Toronto and Hospital for Sick Children, 555 University Ave., Toronto, ON, Canada, M5G1X8

Abstract

Closed-field stimulation of one ear, at high sound intensity, will activate both ears because of bone/soft tissuetransmission of the acoustic signal across the skull. In human psychophysics and in clinical audiometry a knowledgeof interaural attenuation values is important, particularly when assessing asymmetrical hearing loss or in studies of monaural hearing. Similarly, in testing monaural hearing in experimental animal studies, acoustic cross-over can result in erroneous conclusions about hearing function. The mouse has become a widely used animal model for various types of hearing loss, especially those relating to gene mutations, and also for age related deafness (presbycusis). In the present study we have measured acoustic cross-over in this species using a novel bio-assay technique based on auditory brainstem evoked responses (ABR). We report here for the mouse, an interaural attenuation of 37-45dB for click and 32kHz toneburst

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How to Cite

1.
Harrison AL, Negandhi J, Allemang C, D’Alessandro L, Harrison RV. Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay. Canadian Acoustics [Internet]. 2013 Mar. 1 [cited 2021 Oct. 25];41(1). Available from: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/2597

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Section

Article - Hearing Sciences