Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay

Auteurs-es

  • Adrienne L. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Jaina Negandhi Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Cullen Allemang Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Lisa D’Alessandro Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children
  • Robert V. Harrison Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Auditory Science Laboratory, Neuroscience and Mental Health Program, The Hospital for Sick Children; Department of Otolaryngology-Head and Neck Surgery, University of Toronto and Hospital for Sick Children, 555 University Ave., Toronto, ON, Canada, M5G1X8

Résumé

La stimulation de l’oreille unique à haute intensité sonore, en sphère fermée, cause l’activation des deux oreilles dù à la transmission du signal acoustique à travers les tissus mous et l’os du crâne. En psychophysique de l'homme et l’audiométrie clinique, l'atténuation interaural doit être connue dans les études d'audience mono ou de la surdité asymétrique. De même, pour tester l'audition monaurale dans les études expérimentales chez les animaux, la transmission trans-crânienne (aguillage acoustique) peut produire des conclusions erronées au sujet de la fonction auditive. La souris est devenue le modèle animal largement utilisé pour différents types de pertes auditives, en particulier celles qui ont a trait à des mutations géniques, et aussi de la surdité liée à l'âge (presbyacousie). Dans l’étude en question, nous avons mesuré la transmission trans-crânienne (aguillage acoustique) chez cette espèce en utilisant une technique de dosage biologique basée sur les potentiels évoqués auditifs (PEA). Nous rapportons ici chez la souris, une atténuation interaural de 37-45dB pour le clic et le 32kHz pip tonal.

Fichiers supplémentaires

Comment citer

1.
Harrison AL, Negandhi J, Allemang C, D’Alessandro L, Harrison RV. Acoustic Cross-Over Between the Ears in Mice (Mus Musculus) Determined Using a Novel ABR Based Bio-Assay. Canadian Acoustics [Internet]. 1 mars 2013 [cité 18 juill. 2024];41(1). Disponible à: https://jcaa.caa-aca.ca/index.php/jcaa/article/view/2597

Numéro

Vol. 41 No. 1 (2013)

Rubrique

Article - Sciences de l'audition

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