Monitoring fluidized-bed drying of pharmaceutical granules using acoustic sensors

Derek Daniher, Lauren Briens

Abstract


Fluidized bed drying of pharmaceutical granules using acoustic monitors is described. Acoustic monitoring is non-intrusive, cheap and requires no modification to existing fluidized bed drying equipment if a microphone is externally located. It is useful monitoring tool in high-shear wet granulation, pneumatic transport and rotary drying. The application of fluidized-bed drying monitoring is based on the fact that the sound produced by the collisions of dry granules is different from sound produced by the collision of moist granules.

Keywords


Drying; Fluidized beds; Granular materials; Granulation; Microphones; Pneumatics; Sensors; Acoustic Sensors; High-shear wet granulation; Moist granules; Pneumatic transport

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