A comparison of imaging modalities to monitor thermal and mechanical ultrasound tissue therapies

Arthur Worthington, Sankar Narasimhan, Jahan Tavakkoli, Michael C. Kolios

Abstract


A study was conducted to compare the ability of conventional ultrasound imaging, transmission ultrasound imaging, and photoacoustic imaging to discriminate lesions created by high intensity therapeutic ultrasound. These lesions resulted in thermally and mechanically induced tissue destruction. High intensity focused ultrasound (HIFU) was used to create thermal lesions by coagulating the target tissue. A SONIX RP® clinical imaging system was used to monitor lesion growth in real time pre- during post-exposure through its endocavity 6MHz convex array probe that was coaxially mounted in the center of the therapy transducer. The coaxial transducer showed the location of the focal spot during the exposure. It was observed that two different high intensity ultrasound lesions were formed and three modalities adopted in assessing the lesions.

Keywords


Acoustic waves; Medical imaging; Optoelectronic devices; Piezoelectric transducers; Ultrasonic testing; Ultrasonic transmission; Ultrasonics; Array probe; Clinical imaging systems; Focal spot; High intensity focused ultrasound; High intensity ultrasounds; High-intensity therapeutic ultrasound; Imaging modality; Photo-acoustic imaging; Post-exposure; Real time; Target tissues; Therapy transducers; Thermal lesion; Tissue destruction; Transmission ultrasound imaging; Ultrasound imaging

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