Effects of high-intensity focused ultrasound with different acoustic doses on neural tissues in vitro
Keywords:Histology, Transducers, Ultrasonics, Dose-dependent, Focal zones, HIFU transducers, High intensity focused ultrasound, Imaging probe, In-vitro, Mechanical mechanisms, Neural tissue, Surgical procedures, Treatment parameters
AbstractReplacing invasive surgical procedures with non-invasive, bloodless interventions can lead to significant advancements in the field of medicine. The product of the acoustic intensity and sonication time yields a treatment parameter that was tenned acoustic dose. The goal of this study is to investigate the dose-dependent biologic effects of HIFU on lobster's ventral nerve cord in vitro. Because the HIFU transducer is strongly focused, both low and medium-level acoustic doses were achieved by placing the neural tissue in the pie-focal region of the HIFU transducer. The imaging probe was aligned with the therapeutic HIFU transducer such that the focal zone of the therapeutic transducer appears on the screen of the ultrasound imager, thereby guiding the acoustic therapy to the target. On the other hand, increase in the nerve CAP amplitude after HIFU treatment at low-level acoustic dose demonstrates the ability of HIFU to stimulate neural tissues primarily due to its mechanical mechanism.
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